Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content

Amyotrophic lateral sclerosis (ALS) is a late-onset neurological disorder characterized by death of motoneurons. Mutations in Cu/Zn superoxide dismutase-1 (SOD1) cause familial ALS but the mechanisms whereby they induce disease are not fully understood. Here, we use time-lapse microscopy to monitor...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: De Vos, Kurt J., Chapman, Anna L., Tennant, Maria E., Manser, Catherine, Tudor, Elizabeth L., Lau, Kwok-Fai, Brownlees, Janet, Ackerley, Steven, Shaw, Pamela J., McLoughlin, Declan M., Shaw, Christopher E., Leigh, P. Nigel, Miller, Christopher C.J., Grierson, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516806/
https://ncbi.nlm.nih.gov/pubmed/17725983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddm226
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados