Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport

Neurofilaments are synthesised in neuronal cell bodies and then transported through axons. Damage to neurofilament transport is seen in amyotrophic lateral sclerosis (ALS). Here, we show that PKN1, a neurofilament head–rod domain kinase is cleaved and activated in SOD1G93A transgenic mice that are a...

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Udgivet i:FEBS Lett
Main Authors: Manser, Catherine, Stevenson, Alison, Banner, Steven, Davies, Jennifer, Tudor, Elizabeth L., Ono, Yoshitaka, Leigh, P. Nigel, McLoughlin, Declan M., Shaw, Christopher E., Miller, Christopher C.J.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516414/
https://ncbi.nlm.nih.gov/pubmed/18519042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2008.05.034
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