Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport

Neurofilaments are synthesised in neuronal cell bodies and then transported through axons. Damage to neurofilament transport is seen in amyotrophic lateral sclerosis (ALS). Here, we show that PKN1, a neurofilament head–rod domain kinase is cleaved and activated in SOD1G93A transgenic mice that are a...

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Enregistré dans:
Détails bibliographiques
Publié dans:FEBS Lett
Auteurs principaux: Manser, Catherine, Stevenson, Alison, Banner, Steven, Davies, Jennifer, Tudor, Elizabeth L., Ono, Yoshitaka, Leigh, P. Nigel, McLoughlin, Declan M., Shaw, Christopher E., Miller, Christopher C.J.
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516414/
https://ncbi.nlm.nih.gov/pubmed/18519042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2008.05.034
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