Drug resistance in protozoan parasites

gan de Koning, Harry P.
Cyhoeddwyd yn Emerg Top Life Sci (2017)

Purine Nucleobase Transport in Amastigotes of Leishmania mexicana: Involvement in Allopurinol Uptake

gan Al-Salabi, Mohammed I., de Koning, Harry P.
Cyhoeddwyd 2005

Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei

gan Munday, Jane C., Settimo, Luca, de Koning, Harry P.
Cyhoeddwyd yn Front Pharmacol (2015)

Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story

gan Baker, Nicola, de Koning, Harry P., Mäser, Pascal, Horn, David
Cyhoeddwyd 2013

SAR Studies of Diphenyl Cationic Trypanocides: Superior Activity of Phosphonium over Ammonium Salts

gan Dardonville, Christophe, Alkhaldi, Abdulsalam A. M., De Koning, Harry P.
Cyhoeddwyd yn ACS Med Chem Lett (2014)

An improved and highly sensitive microfluorimetric method for assessing susceptibility of Plasmodium falciparum to antimalarial drugs in vitro

gan Quashie, Neils B, de Koning, Harry P, Ranford-Cartwright, Lisa C
Cyhoeddwyd 2006

Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Tr...

gan Quashie, Neils B, Ranford-Cartwright, Lisa C, de Koning, Harry P
Cyhoeddwyd 2010

The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference!

gan Tagoe, Daniel N. A., Kalejaiye, Titilola D., de Koning, Harry P.
Cyhoeddwyd yn Front Pharmacol (2015)

Exploiting the Achilles’ heel of membrane trafficking in trypanosomes

gan Zoltner, Martin, Horn, David, de Koning, Harry P, Field, Mark C
Cyhoeddwyd yn Curr Opin Microbiol (2016)

Antileishmanial and antitrypanosomal activity of symmetrical dibenzyl-substituted α,β-unsaturated carbonyl-based compounds

gan Alkhaldi, Abdulsalam AM, de Koning, Harry P, Bukhari, Syed Nasir Abbas
Cyhoeddwyd yn Drug Des Devel Ther (2019)

Trypanosoma brucei Methylthioadenosine Phosphorylase Protects the Parasite from the Antitrypanosomal Effect of Deoxyadenosine: IMPLICATIONS FOR THE PHARMACOLOGY OF ADENOSINE ANTIME...

gan Vodnala, Munender, Ranjbarian, Farahnaz, Pavlova, Anna, de Koning, Harry P., Hofer, Anders
Cyhoeddwyd yn J Biol Chem (2016)

Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity()

gan Lüscher, Alexandra, Lamprea-Burgunder, Estelle, Graf, Fabrice E., de Koning, Harry P., Mäser, Pascal
Cyhoeddwyd 2013

The animal trypanosomiases and their chemotherapy: a review

gan GIORDANI, FEDERICA, MORRISON, LIAM J., ROWAN, TIM G., DE KONING, HARRY P., BARRETT, MICHAEL P.
Cyhoeddwyd yn Parasitology (2016)

Multi-target mode of action of a Clerodane-type diterpenoid from Polyalthia longifolia targeting African trypanosomes

gan Ebiloma, Godwin U., Katsoulis, Evangelos, Igoli, John O., Gray, Alexander I., De Koning, Harry P.
Cyhoeddwyd yn Sci Rep (2018)

The individual components of commercial isometamidium do not possess stronger trypanocidal activity than the mixture, nor bypass isometamidium resistance

gan Eze, Anthonius A., Igoli, John, Gray, Alexander I., Skellern, Graham G., De Koning, Harry P.
Cyhoeddwyd yn Int J Parasitol Drugs Drug Resist (2019)

Trypanocidal Furamidine Analogues: Influence of Pyridine Nitrogens on Trypanocidal Activity, Transport Kinetics, and Resistance Patterns

gan Ward, Christopher P., Wong, Pui Ee, Burchmore, Richard J., de Koning, Harry P., Barrett, Michael P.
Cyhoeddwyd 2011

Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

gan Graf, Fabrice E., Baker, Nicola, Munday, Jane C., de Koning, Harry P., Horn, David, Mäser, Pascal
Cyhoeddwyd yn Int J Parasitol Drugs Drug Resist (2015)

Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei

gan Alkhaldi, Abdulsalam A.M., Martinek, Jan, Panicucci, Brian, Dardonville, Christophe, Zíková, Alena, de Koning, Harry P.
Cyhoeddwyd yn Int J Parasitol Drugs Drug Resist (2015)

Genotypic Status of the TbAT1/P2 Adenosine Transporter of Trypanosoma brucei gambiense Isolates from Northwestern Uganda following Melarsoprol Withdrawal

gan Kazibwe, Anne J. N., Nerima, Barbara, de Koning, Harry P., Mäser, Pascal, Barrett, Michael P., Matovu, Enock
Cyhoeddwyd 2009

9-(2′-Deoxy-2′-Fluoro-β-d-Arabinofuranosyl) Adenine Is a Potent Antitrypanosomal Adenosine Analogue That Circumvents Transport-Related Drug Resistance

gan Ranjbarian, Farahnaz, Vodnala, Munender, Alzahrani, Khalid J. H., Ebiloma, Godwin U., de Koning, Harry P., Hofer, Anders
Cyhoeddwyd yn Antimicrob Agents Chemother (2017)