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Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei

Lipophilic bisphosphonium salts are among the most promising antiprotozoal leads currently under investigation. As part of their preclinical evaluation we here report on their mode of action against African trypanosomes, the etiological agents of sleeping sickness. The bisphosphonium compounds CD38...

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Bibliografische gegevens
Gepubliceerd in:Int J Parasitol Drugs Drug Resist
Hoofdauteurs: Alkhaldi, Abdulsalam A.M., Martinek, Jan, Panicucci, Brian, Dardonville, Christophe, Zíková, Alena, de Koning, Harry P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805778/
https://ncbi.nlm.nih.gov/pubmed/27054061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2015.12.002
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