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Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei

Lipophilic bisphosphonium salts are among the most promising antiprotozoal leads currently under investigation. As part of their preclinical evaluation we here report on their mode of action against African trypanosomes, the etiological agents of sleeping sickness. The bisphosphonium compounds CD38...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Parasitol Drugs Drug Resist
Prif Awduron: Alkhaldi, Abdulsalam A.M., Martinek, Jan, Panicucci, Brian, Dardonville, Christophe, Zíková, Alena, de Koning, Harry P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805778/
https://ncbi.nlm.nih.gov/pubmed/27054061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2015.12.002
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