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Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei

Lipophilic bisphosphonium salts are among the most promising antiprotozoal leads currently under investigation. As part of their preclinical evaluation we here report on their mode of action against African trypanosomes, the etiological agents of sleeping sickness. The bisphosphonium compounds CD38...

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Detalhes bibliográficos
Publicado no:Int J Parasitol Drugs Drug Resist
Main Authors: Alkhaldi, Abdulsalam A.M., Martinek, Jan, Panicucci, Brian, Dardonville, Christophe, Zíková, Alena, de Koning, Harry P.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805778/
https://ncbi.nlm.nih.gov/pubmed/27054061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2015.12.002
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