Pyrimidine Salvage in Trypanosoma brucei Bloodstream Forms and the Trypanocidal Action of Halogenated Pyrimidiness

African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host. However, uptake of pyrimidines in bloodstream form trypanosomes has not been investigated, making it difficult to judge the relative importance of salvage and synthesis or to design a...

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Gepubliceerd in:Mol Pharmacol
Hoofdauteurs: Ali, Juma A. M., Creek, Darren J., Burgess, Karl, Allison, Harriet C., Field, Mark C., Mäser, Pascal, De Koning, Harry P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857052/
https://ncbi.nlm.nih.gov/pubmed/23188714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.082321
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