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Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity()

African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de novo and import purines from their hosts to build nucleic acids. The purine salvage pathways of Trypanosoma brucei being redundant, none of the involved enzymes is likely to be essential. Nevertheless they can b...

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Bibliografiske detaljer
Main Authors: Lüscher, Alexandra, Lamprea-Burgunder, Estelle, Graf, Fabrice E., de Koning, Harry P., Mäser, Pascal
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940079/
https://ncbi.nlm.nih.gov/pubmed/24596669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2013.12.001
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