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Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity()

African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de novo and import purines from their hosts to build nucleic acids. The purine salvage pathways of Trypanosoma brucei being redundant, none of the involved enzymes is likely to be essential. Nevertheless they can b...

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Bibliografische gegevens
Hoofdauteurs: Lüscher, Alexandra, Lamprea-Burgunder, Estelle, Graf, Fabrice E., de Koning, Harry P., Mäser, Pascal
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940079/
https://ncbi.nlm.nih.gov/pubmed/24596669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2013.12.001
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