Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol.

The predominant mechanism of drug resistance in African trypanosomes is decreased drug uptake due to loss-of-function mutations in the genes for the transporters that mediate drug import. The role of transporters as determinants of drug susceptibility is well documented from laboratory-selected Tryp...

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Bibliografiske detaljer

Principais autores:	Fabrice E Graf, Philipp Ludin, Tanja Wenzler, Marcel Kaiser, Reto Brun, Patient Pati Pyana, Philippe Büscher, Harry P de Koning, David Horn, Pascal Mäser
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science (PLoS) 2013-01-01
Serier:	PLoS Neglected Tropical Diseases
Online adgang:	https://doi.org/10.1371/journal.pntd.0002475
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