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SAR Studies of Diphenyl Cationic Trypanocides: Superior Activity of Phosphonium over Ammonium Salts
[Image: see text] In previous studies, we have shown that phosphonium salt diphenyl derivatives are attractive antitrypanosomal hit compounds with EC(50) values against Trypanosoma brucei in the nanomolar range. To evaluate the role of the cationic center on the trypanocidal activity and extend the...
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| Publié dans: | ACS Med Chem Lett |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Chemical
Society
2014
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4329581/ https://ncbi.nlm.nih.gov/pubmed/25699142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500408d |
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