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Multi-target mode of action of a Clerodane-type diterpenoid from Polyalthia longifolia targeting African trypanosomes

Natural products have made remarkable contributions to drug discovery and therapy. In this work we exploited various biochemical approaches to investigate the mode of action of 16-α-hydroxy-cleroda-3,13 (14)-Z-dien-15,16-olide (HDK-20), which we recently isolated from Polyalthia longifolia, on Trypa...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Ebiloma, Godwin U., Katsoulis, Evangelos, Igoli, John O., Gray, Alexander I., De Koning, Harry P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854603/
https://ncbi.nlm.nih.gov/pubmed/29545637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22908-3
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