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Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei

Drug resistance in pathogenic protozoa is very often caused by changes to the ‘transportome’ of the parasites. In Trypanosoma brucei, several transporters have been implicated in uptake of the main classes of drugs, diamidines and melaminophenyl arsenicals. The resistance mechanism had been thought...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Munday, Jane C., Settimo, Luca, de Koning, Harry P.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356943/
https://ncbi.nlm.nih.gov/pubmed/25814953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00032
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