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Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei

Drug resistance in pathogenic protozoa is very often caused by changes to the ‘transportome’ of the parasites. In Trypanosoma brucei, several transporters have been implicated in uptake of the main classes of drugs, diamidines and melaminophenyl arsenicals. The resistance mechanism had been thought...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Munday, Jane C., Settimo, Luca, de Koning, Harry P.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356943/
https://ncbi.nlm.nih.gov/pubmed/25814953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00032
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