The Diamagnetic Susceptibility of the Tubulin Dimer

le Bras, Wim, Torbet, James, Diakun, Gregory P., Rikken, Geert L. J. A., Diaz, J. Fernando
Foilsithe 2014

Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration

le Field, Jessica J., Northcote, Peter T., Paterson, Ian, Altmann, Karl-Heinz, Díaz, J. Fernando, Miller, John H.
Foilsithe in Int J Mol Sci (2017)

Synthesis, Microtubule-Binding Affinity, and Antiproliferative Activity of New Epothilone Analogs and of an EGFR-Targeted Epothilone-Peptide Conjugate

le Gaugaz, Fabienne Zdenka, Chicca, Andrea, Redondo-Horcajo, Mariano, Barasoain, Isabel, Díaz, J. Fernando, Altmann, Karl-Heinz
Foilsithe in Int J Mol Sci (2019)

Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin

le Sharma, Ashwani, Sáez-Calvo, Gonzalo, Olieric, Natacha, de Asís Balaguer, Francisco, Barasoain, Isabel, Lamberth, Clemens, Díaz, J. Fernando, Steinmetz, Michel O.
Foilsithe in Int J Mol Sci (2017)

Insights into the distinct mechanisms of action of taxane and non-taxane microtubule stabilizers from cryo-EM structures

le Kellogg, Elizabeth H., Hejab, Nisreen M. A., Howes, Stuart, Northcote, Peter, Miller, John H., Díaz, J. Fernando, Downing, Kenneth H., Nogales, Eva
Foilsithe in J Mol Biol (2017)

Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones)

le Jantsch, Andrea, Nieto, Lidia, Gertsch, Jürg, Rodríguez-Salarichs, Javier, Matesanz, Ruth, Jiménez-Barbero, Jesús, Díaz, J. Fernando, Canales, Ángeles, Altmann, Karl-Heinz
Foilsithe in Molecules (2016)

TRAPPII regulates exocytic Golgi exit by mediating nucleotide exchange on the Ypt31 ortholog RabE(RAB11)

le Pinar, Mario, Arst, Herbert N., Pantazopoulou, Areti, Tagua, Víctor G., de los Ríos, Vivian, Rodríguez-Salarichs, Javier, Díaz, J. Fernando, Peñalva, Miguel A.
Foilsithe in Proc Natl Acad Sci U S A (2015)

Cpl-7, a Lysozyme Encoded by a Pneumococcal Bacteriophage with a Novel Cell Wall-binding Motif

le Bustamante, Noemí, Campillo, Nuria E., García, Ernesto, Gallego, Cristina, Pera, Benet, Diakun, Gregory P., Sáiz, José Luis, García, Pedro, Díaz, J. Fernando, Menéndez, Margarita
Foilsithe 2010

A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

le Prota, Andrea E., Bargsten, Katja, Diaz, J. Fernando, Marsh, May, Cuevas, Carmen, Liniger, Marc, Neuhaus, Christian, Andreu, Jose M., Altmann, Karl-Heinz, Steinmetz, Michel O.
Foilsithe 2014

Cytotoxic Activity and Chemical Composition of the Root Extract from the Mexican Species Linum scabrellum: Mechanism of Action of the Active Compound 6-Methoxypodophyllotoxin

le Alejandre-García, Ivonne, Álvarez, Laura, Cardoso-Taketa, Alexandre, González-Maya, Leticia, Antúnez, Mayra, Salas-Vidal, Enrique, Díaz, J. Fernando, Marquina-Bahena, Silvia, Villarreal, María Luisa
Foilsithe in Evid Based Complement Alternat Med (2015)

High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells

le Pera, Benet, Calvo-Vidal, M. Nieves, Ambati, Srikanth, Jordi, Michel, Kahn, Alissa, Díaz, J. Fernando, Fang, Weishuo, Altmann, Karl-Heinz, Cerchietti, Leandro, Moore, Malcolm A.S.
Foilsithe in Cancer Lett (2015)

Self-Organization of FtsZ Polymers in Solution Reveals Spacer Role of the Disordered C-Terminal Tail

le Huecas, Sonia, Ramírez-Aportela, Erney, Vergoñós, Albert, Núñez-Ramírez, Rafael, Llorca, Oscar, Díaz, J. Fernando, Juan-Rodríguez, David, Oliva, María A., Castellen, Patricia, Andreu, José M.
Foilsithe in Biophys J (2017)

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

le Menchon, Grégory, Prota, Andrea E., Lucena-Agell, Daniel, Bucher, Pascal, Jansen, Rolf, Irschik, Herbert, Müller, Rolf, Paterson, Ian, Díaz, J. Fernando, Altmann, Karl-Heinz, Steinmetz, Michel O.
Foilsithe in Nat Commun (2018)

High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design

le Bueno, Oskía, Estévez Gallego, Juan, Martins, Solange, Prota, Andrea E., Gago, Federico, Gómez-SanJuan, Asier, Camarasa, María-José, Barasoain, Isabel, Steinmetz, Michel O., Díaz, J. Fernando, Pérez-Pérez, María-Jesús, Liekens, Sandra, Priego, Eva-María
Foilsithe in Sci Rep (2018)

Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site

le Matthew, Susan, Chen, Qi-Yin, Ratnayake, Ranjala, Fermaintt, Charles S., Lucena-Agell, Daniel, Bonato, Francesca, Prota, Andrea E., Lim, Seok Ting, Wang, Xiaomeng, Díaz, J. Fernando, Risinger, April L., Paul, Valerie J., Oliva, Maria Ángela, Luesch, Hendrik
Foilsithe in Proc Natl Acad Sci U S A (2021)

Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells

le Trigili, Chiara, Barasoain, Isabel, Sánchez-Murcia, Pedro A., Bargsten, Katja, Redondo-Horcajo, Mariano, Nogales, Aurora, Gardner, Nicola M., Meyer, Arndt, Naylor, Guy J., Gómez-Rubio, Elena, Gago, Federico, Steinmetz, Michel O., Paterson, Ian, Prota, Andrea E., Díaz, J. Fernando
Foilsithe in ACS Omega (2016)

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

le Balaguer, Francisco de Asís, Mühlethaler, Tobias, Estévez-Gallego, Juan, Calvo, Enrique, Giménez-Abián, Juan Francisco, Risinger, April L., Sorensen, Erik J., Vanderwal, Christopher D., Altmann, Karl-Heinz, Mooberry, Susan L., Steinmetz, Michel O., Oliva, María Ángela, Prota, Andrea E., Díaz, J. Fernando
Foilsithe in Int J Mol Sci (2019)

Structural model for differential cap maturation at growing microtubule ends

le Estévez-Gallego, Juan, Josa-Prado, Fernando, Ku, Siou, Buey, Ruben M, Balaguer, Francisco A, Prota, Andrea E, Lucena-Agell, Daniel, Kamma-Lorger, Christina, Yagi, Toshiki, Iwamoto, Hiroyuki, Duchesne, Laurence, Barasoain, Isabel, Steinmetz, Michel O, Chrétien, Denis, Kamimura, Shinji, Díaz, J Fernando, Oliva, Maria A
Foilsithe in eLife (2020)

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

le Bohnacker, Thomas, Prota, Andrea E., Beaufils, Florent, Burke, John E., Melone, Anna, Inglis, Alison J., Rageot, Denise, Sele, Alexander M., Cmiljanovic, Vladimir, Cmiljanovic, Natasa, Bargsten, Katja, Aher, Amol, Akhmanova, Anna, Díaz, J. Fernando, Fabbro, Doriano, Zvelebil, Marketa, Williams, Roger L., Steinmetz, Michel O., Wymann, Matthias P.
Foilsithe in Nat Commun (2017)

Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells

le Peronne, Lauralie, Denarier, Eric, Rai, Ankit, Prudent, Renaud, Vernet, Audrey, Suzanne, Peggy, Ramirez-Rios, Sacnicté, Michallet, Sophie, Guidetti, Mélanie, Vollaire, Julien, Lucena-Agell, Daniel, Ribba, Anne-Sophie, Josserand, Véronique, Coll, Jean-Luc, Dallemagne, Patrick, Díaz, J. Fernando, Oliva, María Ángela, Sadoul, Karin, Akhmanova, Anna, Andrieux, Annie, Lafanechère, Laurence
Foilsithe in Cancers (Basel) (2020)