Microtubule-Stabilizing Drugs from Marine Sponges: Focus on Peloruside A and Zampanolide

Por Miller, John H., Singh, A. Jonathan, Northcote, Peter T.
Publicado em 2010

Inhibition of Ribosome Recruitment Induces Stress Granule Formation Independently of Eukaryotic Initiation Factor 2α Phosphorylation

Por Mazroui, Rachid, Sukarieh, Rami, Bordeleau, Marie-Eve, Kaufman, Randal J., Northcote, Peter, Tanaka, Junichi, Gallouzi, Imed, Pelletier, Jerry
Publicado em 2006

Insights into the distinct mechanisms of action of taxane and non-taxane microtubule stabilizers from cryo-EM structures

Por Kellogg, Elizabeth H., Hejab, Nisreen M. A., Howes, Stuart, Northcote, Peter, Miller, John H., Díaz, J. Fernando, Downing, Kenneth H., Nogales, Eva
Publicado no J Mol Biol (2017)

Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation

Por Bordeleau, Marie-Eve, Matthews, James, Wojnar, Joanna M., Lindqvist, Lisa, Novac, Olivia, Jankowsky, Eckhard, Sonenberg, Nahum, Northcote, Peter, Teesdale-Spittle, Paul, Pelletier, Jerry
Publicado em 2005

Hallmarks of Molecular Action of Microtubule Stabilizing Agents: EFFECTS OF EPOTHILONE B, IXABEPILONE, PELORUSIDE A, AND LAULIMALIDE ON MICROTUBULE CONFORMATION

Por Khrapunovich-Baine, Marina, Menon, Vilas, Yang, Chia-Ping Huang, Northcote, Peter T., Miller, John H., Angeletti, Ruth Hogue, Fiser, Andras, Horwitz, Susan Band, Xiao, Hui
Publicado em 2011

Peloruside B, a Potent Antitumor Macrolide from the New Zealand Marine Sponge Mycale hentscheli: Isolation, Structure, Total Synthesis and Bioactivity

Por Singh, A. Jonathan, Xu, Chun-Xiao, Xu, Xiaoming, West, Lyndon M., Wilmes, Anja, Chan, Ariane, Hamel, Ernest, Miller, John H., Northcote, Peter T., Ghosh, Arun K.
Publicado em 2010

Peloruside- and Laulimalide-Resistant Human Ovarian Carcinoma Cells Have βI-Tubulin Mutations and Altered Expression of βII- and βIII-Tubulin Isotypes

Por Kanakkanthara, Arun, Wilmes, Anja, O'Brate, Aurora, Escuin, Daniel, Chan, Ariane, Gjyrezi, Ada, Crawford, Janet, Rawson, Pisana, Kivell, Bronwyn, Northcote, Peter T., Hamel, Ernest, Giannakakou, Paraskevi, Miller, John H.
Publicado em 2011

Mitochondrial Genome-Knockout Cells Demonstrate a Dual Mechanism of Action for the Electron Transport Complex I Inhibitor Mycothiazole

Por Meyer, Kirsten J., Singh, A. Jonathan, Cameron, Alanna, Tan, An S., Leahy, Dora C., O’Sullivan, David, Joshi, Praneta, La Flamme, Anne C., Northcote, Peter T., Berridge, Michael V., Miller, John H.
Publicado em 2012

Zampanolide, a potent new microtubule stabilizing agent, covalently reacts with the taxane luminal site in both tubulin α,β-heterodimers and microtubules

Por Field, Jessica J., Pera, Benet, Calvo, Enrique, Canales, Angeles, Zurwerra, Didier, Trigili, Chiara, Rodríguez-Salarichs, Javier, Matesanz, Ruth, Kanakkanthara, Arun, Wakefield, St. John, Singh, A. Jonathan, Jiménez-Barbero, Jesús, Northcote, Peter, Miller, John H., López, Juan Antonio, Hamel, Ernest, Barasoain, Isabel, Altmann, Karl-Heinz, Díaz, José Fernando
Publicado em 2012