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Insights into the distinct mechanisms of action of taxane and non-taxane microtubule stabilizers from cryo-EM structures
A number of microtubule-stabilizing agents have demonstrated or predicted potential as anticancer agents, but a detailed structural basis for their mechanism of action is still lacking. We have obtained high-resolution (3.9 – 4.2 Å) cryo-EM reconstructions of microtubules stabilized by the taxane-si...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5325780/ https://ncbi.nlm.nih.gov/pubmed/28104363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.01.001 |
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