Insights into the distinct mechanisms of action of taxane and non-taxane microtubule stabilizers from cryo-EM structures

A number of microtubule-stabilizing agents have demonstrated or predicted potential as anticancer agents, but a detailed structural basis for their mechanism of action is still lacking. We have obtained high-resolution (3.9 – 4.2 Å) cryo-EM reconstructions of microtubules stabilized by the taxane-si...

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Veröffentlicht in:J Mol Biol
Hauptverfasser: Kellogg, Elizabeth H., Hejab, Nisreen M. A., Howes, Stuart, Northcote, Peter, Miller, John H., Díaz, J. Fernando, Downing, Kenneth H., Nogales, Eva
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325780/
https://ncbi.nlm.nih.gov/pubmed/28104363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.01.001
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