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Near-atomic model of microtubule-tau interactions
Tau is a developmentally regulated axonal protein that stabilizes and bundles microtubules (MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent aggregation into fibrils implicated in Alzheimer’s disease. It is unclear which tau residues are crucial for tau-MT intera...
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| Publié dans: | Science |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6225777/ https://ncbi.nlm.nih.gov/pubmed/29748322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aat1780 |
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