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Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation

RNA helicases are the largest group of enzymes in eukaryotic RNA metabolism. The DEXD/H-box putative RNA helicases form the helicase superfamily II, whose members are defined by seven highly conserved amino acid motifs, making specific targeting of selected members a challenging pharmacological prob...

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Detalhes bibliográficos
Main Authors: Bordeleau, Marie-Eve, Matthews, James, Wojnar, Joanna M., Lindqvist, Lisa, Novac, Olivia, Jankowsky, Eckhard, Sonenberg, Nahum, Northcote, Peter, Teesdale-Spittle, Paul, Pelletier, Jerry
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1176247/
https://ncbi.nlm.nih.gov/pubmed/16030146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504249102
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