Hallmarks of Molecular Action of Microtubule Stabilizing Agents: EFFECTS OF EPOTHILONE B, IXABEPILONE, PELORUSIDE A, AND LAULIMALIDE ON MICROTUBULE CONFORMATION

Microtubule stabilizing agents (MSAs) comprise a class of drugs that bind to microtubule (MT) polymers and stabilize them against disassembly. Several of these agents are currently in clinical use as anticancer drugs, whereas others are in various stages of development. Nonetheless, there is insuffi...

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Detalhes bibliográficos
Main Authors: Khrapunovich-Baine, Marina, Menon, Vilas, Yang, Chia-Ping Huang, Northcote, Peter T., Miller, John H., Angeletti, Ruth Hogue, Fiser, Andras, Horwitz, Susan Band, Xiao, Hui
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064228/
https://ncbi.nlm.nih.gov/pubmed/21245138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.162214
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