Insights into the mechanism of microtubule stabilization by Taxol

The antitumor drug Taxol stabilizes microtubules and reduces their dynamicity, promoting mitotic arrest and cell death. Upon assembly of the α/β-tubulin heterodimer, GTP bound to β-tubulin is hydrolyzed to GDP reaching a steady-state equilibrium between free tubulin dimers and microtubules. The bind...

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Bibliografiske detaljer
Main Authors: Xiao, Hui, Verdier-Pinard, Pascal, Fernandez-Fuentes, Narcis, Burd, Berta, Angeletti, Ruth, Fiser, Andras, Horwitz, Susan Band, Orr, George A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502429/
https://ncbi.nlm.nih.gov/pubmed/16801540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603704103
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