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Structural evidence for cooperative microtubule stabilization by Taxol and the endogenous dynamics regulator MAP4
Microtubules (MTs) composed of αβ-tubulin heterodimers are highly dynamic polymers, whose stability can be regulated by numerous endogenous and exogenous factors. Both the anti-mitotic drug, Taxol, and microtubule-associated proteins (MAPs) stabilize this dynamicity by binding to and altering the co...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3804043/ https://ncbi.nlm.nih.gov/pubmed/22270553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200403x |
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