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The Assembly-Inducing Laulimalide/Peloruside A Binding Site on Tubulin: Molecular Modeling and Biochemical Studies with [(3)H]Peloruside A
We used synthetic peloruside A for the commercial preparation of [(3)H]peloruside A. The radiolabeled compound bound to preformed tubulin polymer in amounts stoichiometric with the polymer’s tubulin content, with an apparent K(d) value of 0.35 µM. A less active peloruside A analogue, (11-R)-pelorusi...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2996141/ https://ncbi.nlm.nih.gov/pubmed/21028850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci1002894 |
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