Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity

por Chen, Qi-Yin, Liu, Yanxia, Luesch, Hendrik
Publicado 2011

Total Synthesis of the Potent Marine-Derived Elastase Inhibitor Lyngbyastatin 7 and In Vitro Biological Evaluation in Model Systems for Pulmonary Diseases

por Luo, Danmeng, Chen, Qi-Yin, Luesch, Hendrik
Publicado en J Org Chem (2015)

Improved Total Synthesis and Biological Evaluation of Potent Apratoxin S4 Based Anticancer Agents with Differential Stability and Further Enhanced Activity

por Chen, Qi-Yin, Liu, Yanxia, Cai, Weijing, Luesch, Hendrik
Publicado 2014

Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors

por Cai, Weijing, Chen, Qi-Yin, Dang, Long H., Luesch, Hendrik
Publicado en ACS Med Chem Lett (2017)

Correction to “Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors”

por Cai, Weijing, Chen, Qi-Yin, Dang, Long H., Luesch, Hendrik
Publicado en ACS Med Chem Lett (2017)

Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: total synthesis of tutuilamide A, serine protease selectivity profile and comparison wit...

por Chen, Qi-Yin, Luo, Danmeng, Seabra, Gustavo M., Luesch, Hendrik
Publicado en Bioorg Med Chem (2020)

Discovery of New A- and B-Type Laxaphycins with Synergistic Anticancer Activity

por Cai, Weijing, Matthew, Susan, Chen, Qi-Yin, Paul, Valerie J., Luesch, Hendrik
Publicado en Bioorg Med Chem (2018)

Discovery, Total Synthesis and SAR of Anaenamides A and B: Anticancer Cyanobacterial Depsipeptides with a Chlorinated Pharmacophore

por Brumley, David A., Gunasekera, Sarath P., Chen, Qi-Yin, Paul, Valerie J., Luesch, Hendrik
Publicado en Org Lett (2020)

Discovery and total synthesis of doscadenamide A: a quorum sensing signaling molecule from a marine cyanobacterium

por Liang, Xiao, Matthew, Susan, Chen, Qi-Yin, Kwan, Jason C., Paul, Valerie J., Luesch, Hendrik
Publicado en Org Lett (2019)

Total synthesis and biological evaluation of apratoxin E and its C30 epimer: configurational reassignment of the natural product

por Wu, Ping, Cai, Weijing, Chen, Qi-Yin, Xu, Senhan, Yin, Ruwen, Li, Yingxia, Zhang, Wei, Luesch, Hendrik
Publicado en Org Lett (2016)

Largazole is a Brain-Penetrant Class I HDAC Inhibitor with Extended Applicability to Glioblastoma and CNS Diseases

por Al-Awadhi, Fatma H., Salvador-Reyes, Lilibeth A., Elsadek, Lobna A., Ratnayake, Ranjala, Chen, Qi-Yin, Luesch, Hendrik
Publicado en ACS Chem Neurosci (2020)

Development of Apratoxin S10 (Apra S10) as an Anti-pancreatic Cancer Agent and Its Preliminary Evaluation in an Orthotopic Patient-derived Xenograft (PDX) Model

por Cai, Weijing, Ratnayake, Ranjala, Gerber, Michael H., Chen, Qi-Yin, Yu, Yichao, Derendorf, Hartmut, Trevino, Jose G., Luesch, Hendrik
Publicado en Invest New Drugs (2018)

Bifunctional Doscadenamides Activate Quorum Sensing in Gram-Negative Bacteria and Synergize with TRAIL to Induce Apoptosis in Cancer Cells

por Liang, Xiao, Chen, Qi-Yin, Seabra, Gustavo M., Matthew, Susan, Kwan, Jason C., Li, Chenglong, Paul, Valerie J., Luesch, Hendrik
Publicado en J Nat Prod (2021)

Design, Synthesis, and Structure-Activity Relationship of a Novel Series of 2-Aryl 5-(4-oxo-3-phenethyl-2-thioxothiazolidin-ylidenemethyl)furans as HIV-1 entry inhibitors

por Katritzky, Alan R., Tala, Srinivasa R., Lu, Hong, Vakulenko, Anatoliy V., Chen, Qi-Yin, Sivapackiam, Jothilingam, Pandya, Keyur, Jiang, Shibo, Debnath, Asim K.
Publicado 2009

Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties

por Salvador, Lilibeth A., Park, Heekwang, Al-Awadhi, Fatma H., Liu, Yanxia, Kim, Bumki, Zeller, Sabrina L., Chen, Qi-Yin, Hong, Jiyong, Luesch, Hendrik
Publicado 2014

Largazole Pharmacokinetics in Rats by LC-MS/MS

por Yu, Mingming, Salvador, Lilibeth A., Sy, Sherwin K. B., Tang, Yufei, Singh, Ravi S. P., Chen, Qi-Yin, Liu, Yanxia, Hong, Jiyong, Derendorf, Hartmut, Luesch, Hendrik
Publicado 2014

Seaweed Natural Products Modify the Host Inflammatory Response via Nrf2 Signaling and Alter Colon Microbiota Composition and Gene Expression

por Bousquet, Michelle S., Ratnayake, Ranjala, Pope, Jillian L., Chen, Qi-Yin, Zhu, Fanchao, Chen, Sixue, Carney, Thomas J., Gharaibeh, Raad Z., Jobin, Christian, Paul, Valerie J., Luesch, Hendrik
Publicado en Free Radic Biol Med (2019)

Apratyramide, a Marine-Derived Peptidic Stimulator of VEGF-A and Other Growth Factors with Potential Application in Wound Healing

por Cai, Weijing, Salvador-Reyes, Lilibeth A., Zhang, Wei, Chen, Qi-Yin, Matthew, Susan, Ratnayake, Ranjala, Seo, Soo Jung, Dolles, Simon, Gibson, Daniel J., Paul, Valerie J., Luesch, Hendrik
Publicado en ACS Chem Biol (2017)

Evaluation of class I HDAC isoform selectivity of largazole analogues

por Kim, Bumki, Park, Heekwang, Salvador, Lilibeth A., Serrano, Patrick E., Kwan, Jason C., Zeller, Sabrina L., Chen, Qi-Yin, Ryu, Soyoung, Liu, Yanxia, Byeon, Seongrim, Luesch, Hendrik, Hong, Jiyong
Publicado 2014

Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site

por Matthew, Susan, Chen, Qi-Yin, Ratnayake, Ranjala, Fermaintt, Charles S., Lucena-Agell, Daniel, Bonato, Francesca, Prota, Andrea E., Lim, Seok Ting, Wang, Xiaomeng, Díaz, J. Fernando, Risinger, April L., Paul, Valerie J., Oliva, Maria Ángela, Luesch, Hendrik
Publicado en Proc Natl Acad Sci U S A (2021)