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Improved Total Synthesis and Biological Evaluation of Potent Apratoxin S4 Based Anticancer Agents with Differential Stability and Further Enhanced Activity
[Image: see text] Apratoxins are cytotoxic natural products originally isolated from marine cyanobacteria that act by preventing cotranslational translocation early in the secretory pathway to downregulate receptor levels and inhibit growth factor secretion, leading to potent antiproliferative activ...
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| Auteurs principaux: | , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Chemical
Society
2014
|
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3993931/ https://ncbi.nlm.nih.gov/pubmed/24660812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4019965 |
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