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Total Synthesis of the Potent Marine-Derived Elastase Inhibitor Lyngbyastatin 7 and In Vitro Biological Evaluation in Model Systems for Pulmonary Diseases
Lyngbyastatin 7 (1) is a marine cyanobacteria-derived lariat-type cyclic depsipeptide, of which the macrocyclic core possesses modified amino acids, including a featured 3-amino-6-hydroxy-2-piperidone (Ahp) moiety and a (Z)-2-amino-2-butenoic acid (Abu) moiety. The first total synthesis of 1 was suc...
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| Publicado no: | J Org Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4734386/ https://ncbi.nlm.nih.gov/pubmed/26709602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.5b02386 |
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