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Total synthesis and biological evaluation of apratoxin E and its C30 epimer: configurational reassignment of the natural product

Apratoxin E provided the inspiration for the design of apratoxin A/E hybrids under preclinical development. Through total synthesis using two different strategies, it was determined that the originally proposed configuration of the thiazoline at C30 is opposite from that in apratoxin A, in contrast...

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Dades bibliogràfiques
Publicat a:Org Lett
Autors principals: Wu, Ping, Cai, Weijing, Chen, Qi-Yin, Xu, Senhan, Yin, Ruwen, Li, Yingxia, Zhang, Wei, Luesch, Hendrik
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386831/
https://ncbi.nlm.nih.gov/pubmed/27723359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.6b02780
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