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Total synthesis and biological evaluation of apratoxin E and its C30 epimer: configurational reassignment of the natural product
Apratoxin E provided the inspiration for the design of apratoxin A/E hybrids under preclinical development. Through total synthesis using two different strategies, it was determined that the originally proposed configuration of the thiazoline at C30 is opposite from that in apratoxin A, in contrast...
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| 出版年: | Org Lett |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5386831/ https://ncbi.nlm.nih.gov/pubmed/27723359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.6b02780 |
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