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Largazole is a Brain-Penetrant Class I HDAC Inhibitor with Extended Applicability to Glioblastoma and CNS Diseases
Largazole is a potent class I selective histone deacetylase (HDAC) inhibitor prodrug with anticancer activity against solid tumors in preclinical models. Largazole possesses in vitro activity against glioblastoma multiforme (GBM) cells and sufficiently crosses the blood-brain barrier based on measur...
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| I publikationen: | ACS Chem Neurosci |
|---|---|
| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2020
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7390227/ https://ncbi.nlm.nih.gov/pubmed/32559056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00093 |
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