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Largazole: From Discovery to Broad-Spectrum Therapy
The cyclic depsipeptide largazole from a cyanobacterium of the genus Symploca is a marine natural product with novel chemical scaffold and potently inhibits class I histone deacetylases (HDACs). Largazole possesses highly differential growth-inhibitory activity, preferentially targeting transformed...
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| Publicat a: | Nat Prod Rep |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4777309/ https://ncbi.nlm.nih.gov/pubmed/22334030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2np00066k |
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