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Synthesis and Biological Evaluation of Largazole Zinc-Binding Group Analogs
Histone acetylation is an extensively investigated post-translational modification that plays an important role as an epigenetic regulator. It is controlled by histone acetyl transferases (HATs) and histone deacetylases (HDACs). The overexpression of HDACs and consequent hypoacetylation of histones...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5494147/ https://ncbi.nlm.nih.gov/pubmed/28416100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.03.071 |
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