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Synthesis and Biological Evaluation of Largazole Analogues with Modified Surface Recognition Cap Groups

Several largazole analogues with modified surface recognition cap groups were synthesized and their HDAC inhibitory activities were determined. The C7-epimer 12 caused negligible inhibition of HDAC activity, failed to induce global histone 3 (H3) acetylation in the HCT116 colorectal cancer cell line...

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書誌詳細
主要な著者: Bhansali, Pravin, Hanigan, Christin L., Perera, Lalith, Casero, Robert A., Viranga Tillekeratne, L. M.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188730/
https://ncbi.nlm.nih.gov/pubmed/25203782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.09.009
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