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Synthesis and Biological Evaluation of Largazole Analogues with Modified Surface Recognition Cap Groups
Several largazole analogues with modified surface recognition cap groups were synthesized and their HDAC inhibitory activities were determined. The C7-epimer 12 caused negligible inhibition of HDAC activity, failed to induce global histone 3 (H3) acetylation in the HCT116 colorectal cancer cell line...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4188730/ https://ncbi.nlm.nih.gov/pubmed/25203782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.09.009 |
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