Anticolon Cancer Activity of Largazole, a Marine-Derived Tunable Histone Deacetylase Inhibitor

Histone deacetylases (HDACs) are validated targets for anticancer therapy as attested by the approval of suberoylanilide hydroxamic acid (SAHA) and romidepsin (FK228) for treating cutaneous T cell lymphoma. We recently described the bioassay-guided isolation, structure determination, synthesis, and...

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Main Authors: Liu, Yanxia, Salvador, Lilibeth A., Byeon, Seongrim, Ying, Yongcheng, Kwan, Jason C., Law, Brian K., Hong, Jiyong, Luesch, Hendrik
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2010
Teme:
Chemotherapy, Antibiotics, and Gene Therapy
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967399/
https://ncbi.nlm.nih.gov/pubmed/20739454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.172387
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