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High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design
Microtubule-targeting agents that bind at the colchicine-site of tubulin are of particular interest in antitumoral therapy due to their dual mechanism of action as antimitotics and vascular disrupting agents. Cyclohexanediones derivatives have been described as a new family of colchicine-domain bind...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5844890/ https://ncbi.nlm.nih.gov/pubmed/29523799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22382-x |
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