Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin

Quinolin-6-yloxyacetamides (QAs) are a chemical class of tubulin polymerization inhibitors that were initially identified as fungicides. Here, we report that QAs are potent anti-proliferative agents against human cancer cells including ones that are drug-resistant. QAs act by disrupting the microtub...

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Udgivet i:Int J Mol Sci
Main Authors: Sharma, Ashwani, Sáez-Calvo, Gonzalo, Olieric, Natacha, de Asís Balaguer, Francisco, Barasoain, Isabel, Lamberth, Clemens, Díaz, J. Fernando, Steinmetz, Michel O.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535829/
https://ncbi.nlm.nih.gov/pubmed/28640209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18071336
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