Parthenolide destabilizes microtubules by covalently modifying tubulin

Detyrosination of the α-tubulin C-terminal tail is a post-translational modification (PTM) of microtubules that is key for many biological processes [1]. Although detyrosination is the oldest known microtubule PTM [2–7], the carboxypeptidase responsible for this modification, VASH1/2-SVBP, was ident...

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Pubblicato in:Curr Biol
Autori principali: Hotta, Takashi, Haynes, Sarah E., Blasius, Teresa L., Gebbie, Margo, Eberhardt, Emily L., Sept, David, Cianfrocco, Michael, Verhey, Kristen J., Nesvizhskii, Alexey I., Ohi, Ryoma
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7931505/
https://ncbi.nlm.nih.gov/pubmed/33482110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2020.11.055
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