Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule

Molecules that alter the normal dynamics of microtubule assembly and disassembly include many anticancer drugs in clinical use. So far all such therapeutics target β-tubulin, and structural biology has explained the basis of their action and permitted design of new drugs. However, by shifting the pr...

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Foilsithe in:Nat Commun
Main Authors: Yang, Jianhong, Wang, Yuxi, Wang, Taijing, Jiang, Jian, Botting, Catherine H., Liu, Huanting, Chen, Qiang, Yang, Jinliang, Naismith, James H., Zhu, Xiaofeng, Chen, Lijuan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931326/
https://ncbi.nlm.nih.gov/pubmed/27357539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12103
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