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Covalent targeting of acquired cysteines in cancer
The thiolate side chain of cysteine has a unique functionality that drug hunters and chemical biologists have begun to exploit. For example, targeting cysteine residues in the ATP-binding pockets of kinases with thiol-reactive molecules has afforded increased selectivity and potency to drugs like im...
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| Publicado no: | Curr Opin Chem Biol |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4731306/ https://ncbi.nlm.nih.gov/pubmed/26629855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2015.11.004 |
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