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Assessing Lysine and Cysteine Reactivities for Designing Targeted Covalent Kinase Inhibitors

Targeted covalent inhibitor design is gaining increasing interest and acceptance. A typical covalent kinase inhibitor design targets a reactive cysteine; however, this strategy is limited due to the low abundance of cysteine and acquired drug resistance from point mutations. Inspired by the recent d...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:J Am Chem Soc
Asıl Yazarlar: Liu, Ruibin, Yue, Zhi, Tsai, Cheng-Chieh, Shen, Jana
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935298/
https://ncbi.nlm.nih.gov/pubmed/30945531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b13248
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