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Assessing Lysine and Cysteine Reactivities for Designing Targeted Covalent Kinase Inhibitors
Targeted covalent inhibitor design is gaining increasing interest and acceptance. A typical covalent kinase inhibitor design targets a reactive cysteine; however, this strategy is limited due to the low abundance of cysteine and acquired drug resistance from point mutations. Inspired by the recent d...
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| Опубликовано в: : | J Am Chem Soc |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6935298/ https://ncbi.nlm.nih.gov/pubmed/30945531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b13248 |
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