Lanean...
Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72
[Image: see text] The covalent inhibition mechanism of action, which overcomes competition with high-affinity, high-abundance substrates of challenging protein targets, can deliver effective chemical probes and drugs. The success of this strategy has centered on exposed cysteine residues as nucleoph...
Gorde:
| Argitaratua izan da: | J Med Chem |
|---|---|
| Egile Nagusiak: | , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Chemical
Society
2019
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| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6959841/ https://ncbi.nlm.nih.gov/pubmed/31725295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01709 |
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