Characterizing the Covalent Targets of a Small Molecule Inhibitor of the Lysine Acetyltransferase P300

[Image: see text] C646 inhibits the lysine acetyltransferases (KATs) p300 and CBP and represents the most potent and selective small molecule KAT inhibitor identified to date. To gain insights into the cellular activity of this epigenetic probe, we applied chemoproteomics to identify covalent target...

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Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Asıl Yazarlar: Shrimp, Jonathan H., Sorum, Alexander W., Garlick, Julie M., Guasch, Laura, Nicklaus, Marc C., Meier, Jordan L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2015
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753543/
https://ncbi.nlm.nih.gov/pubmed/26985290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00385
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