Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in many gene regulatory pathways and protein acetylation events. While p300 inhibitors have been reported, a potent, selective, and readily available active-site directed small molecule inhibitor is not yet know...

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Detalhes bibliográficos
Main Authors: Bowers, Erin M., Yan, Gai, Mukherjee, Chandrani, Orry, Andrew, Wang, Ling, Holbert, Marc A., Crump, Nicholas T., Hazzalin, Catherine A., Liszczak, Glen, Yuan, Hua, Larocca, Cecilia, Saldanha, S. Adrian, Abagyan, Ruben, Sun, Yan, Meyers, David J., Marmorstein, Ronen, Mahadevan, Louis C., Alani, Rhoda M., Cole, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884008/
https://ncbi.nlm.nih.gov/pubmed/20534345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.03.006
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