Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in many gene regulatory pathways and protein acetylation events. While p300 inhibitors have been reported, a potent, selective, and readily available active-site directed small molecule inhibitor is not yet know...

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Bibliografiske detaljer
Main Authors: Bowers, Erin M., Yan, Gai, Mukherjee, Chandrani, Orry, Andrew, Wang, Ling, Holbert, Marc A., Crump, Nicholas T., Hazzalin, Catherine A., Liszczak, Glen, Yuan, Hua, Larocca, Cecilia, Saldanha, S. Adrian, Abagyan, Ruben, Sun, Yan, Meyers, David J., Marmorstein, Ronen, Mahadevan, Louis C., Alani, Rhoda M., Cole, Philip A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884008/
https://ncbi.nlm.nih.gov/pubmed/20534345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.03.006
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