Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in many gene regulatory pathways and protein acetylation events. While p300 inhibitors have been reported, a potent, selective, and readily available active-site directed small molecule inhibitor is not yet know...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Bowers, Erin M., Yan, Gai, Mukherjee, Chandrani, Orry, Andrew, Wang, Ling, Holbert, Marc A., Crump, Nicholas T., Hazzalin, Catherine A., Liszczak, Glen, Yuan, Hua, Larocca, Cecilia, Saldanha, S. Adrian, Abagyan, Ruben, Sun, Yan, Meyers, David J., Marmorstein, Ronen, Mahadevan, Louis C., Alani, Rhoda M., Cole, Philip A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884008/
https://ncbi.nlm.nih.gov/pubmed/20534345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.03.006
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi