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Metabolic Regulation of Histone Acetyltransferases by Endogenous Acyl-CoA Cofactors

The finding that chromatin modifications are sensitive to changes in cellular cofactor levels potentially links altered tumor cell metabolism and gene expression. However, the specific enzymes and metabolites that connect these two processes remain obscure. Characterizing these metabolic-epigenetic...

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Publicado en:Chem Biol
Autores principales: Montgomery, David C., Sorum, Alexander W., Guasch, Laura, Nicklaus, Marc C., Meier, Jordan L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546520/
https://ncbi.nlm.nih.gov/pubmed/26190825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.06.015
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