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Characterizing the Covalent Targets of a Small Molecule Inhibitor of the Lysine Acetyltransferase P300
[Image: see text] C646 inhibits the lysine acetyltransferases (KATs) p300 and CBP and represents the most potent and selective small molecule KAT inhibitor identified to date. To gain insights into the cellular activity of this epigenetic probe, we applied chemoproteomics to identify covalent target...
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| Udgivet i: | ACS Med Chem Lett |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American
Chemical Society
2015
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4753543/ https://ncbi.nlm.nih.gov/pubmed/26985290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00385 |
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