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Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule
Molecules that alter the normal dynamics of microtubule assembly and disassembly include many anticancer drugs in clinical use. So far all such therapeutics target β-tubulin, and structural biology has explained the basis of their action and permitted design of new drugs. However, by shifting the pr...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4931326/ https://ncbi.nlm.nih.gov/pubmed/27357539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12103 |
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