The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in β-tubulin

Inhibitors that bind to the paclitaxel- or vinblastine-binding sites of tubulin have been part of the pharmacopoeia of anticancer therapy for decades. However, tubulin inhibitors that bind to the colchicine-binding site are not used in clinical cancer therapy, because of their low therapeutic index....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yang, Jianhong, Yan, Wei, Yu, Yamei, Wang, Yuxi, Yang, Tao, Xue, Linlin, Yuan, Xue, Long, Caofeng, Liu, Zuowei, Chen, Xiaoxin, Hu, Mengshi, Zheng, Li, Qiu, Qiang, Pei, Heying, Li, Dan, Wang, Fang, Bai, Peng, Wen, Jiaolin, Ye, Haoyu, Chen, Lijuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005456/
https://ncbi.nlm.nih.gov/pubmed/29691282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001658
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