Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

Microtubules, composed of αβ-tubulin heterodimers, have remained popular anticancer targets for decades. Six known binding sites on tubulin dimers have been identified thus far, with five sites on β-tubulin and only one site on α-tubulin, hinting that compounds binding to α-tubulin are less well cha...

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Dades bibliogràfiques
Publicat a:Sci Adv
Autors principals: Yang, Jianhong, Yu, Yamei, Li, Yong, Yan, Wei, Ye, Haoyu, Niu, Lu, Tang, Minghai, Wang, Zhoufeng, Yang, Zhuang, Pei, Heying, Wei, Haoche, Zhao, Min, Wen, Jiaolin, Yang, Linyu, Ouyang, Liang, Wei, Yuquan, Chen, Qiang, Li, Weimin, Chen, Lijuan
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8133757/
https://ncbi.nlm.nih.gov/pubmed/34138737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg4168
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