Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

Microtubules, composed of αβ-tubulin heterodimers, have remained popular anticancer targets for decades. Six known binding sites on tubulin dimers have been identified thus far, with five sites on β-tubulin and only one site on α-tubulin, hinting that compounds binding to α-tubulin are less well cha...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Adv
Principais autores: Yang, Jianhong, Yu, Yamei, Li, Yong, Yan, Wei, Ye, Haoyu, Niu, Lu, Tang, Minghai, Wang, Zhoufeng, Yang, Zhuang, Pei, Heying, Wei, Haoche, Zhao, Min, Wen, Jiaolin, Yang, Linyu, Ouyang, Liang, Wei, Yuquan, Chen, Qiang, Li, Weimin, Chen, Lijuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8133757/
https://ncbi.nlm.nih.gov/pubmed/34138737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg4168
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registros relacionados