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Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect
Microtubules, composed of αβ-tubulin heterodimers, have remained popular anticancer targets for decades. Six known binding sites on tubulin dimers have been identified thus far, with five sites on β-tubulin and only one site on α-tubulin, hinting that compounds binding to α-tubulin are less well cha...
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| Опубликовано в: : | Sci Adv |
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| Главные авторы: | , , , , , , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Association for the Advancement of Science
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8133757/ https://ncbi.nlm.nih.gov/pubmed/34138737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg4168 |
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