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Addition of colchicine-tubulin complex to microtubule ends: The mechanism of substoichiometric colchicine poisoning

Colchicine blocks microtubule polymerization by an unusual substoichiometric poisoning mechanism. We have investigated the mechanism by which this poisoning occurs with several experimental approaches, and have found that colchicine acts by addition to microtubule ends as a colchicine-tubulin comple...

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Bibliografske podrobnosti
Main Authors: Margolis, Robert L., Wilson, Leslie
Format: Artigo
Jezik:Inglês
Izdano: 1977
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC431611/
https://ncbi.nlm.nih.gov/pubmed/269406
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