Addition of colchicine-tubulin complex to microtubule ends: The mechanism of substoichiometric colchicine poisoning
Colchicine blocks microtubule polymerization by an unusual substoichiometric poisoning mechanism. We have investigated the mechanism by which this poisoning occurs with several experimental approaches, and have found that colchicine acts by addition to microtubule ends as a colchicine-tubulin comple...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1977
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431611/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/269406/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.8.3466 |
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